[二氢蝶酸合酶基因突变导致的麻风分枝杆菌对二氨基二苯砜耐药性]
[Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene].
作者信息
Kai Masanori
机构信息
Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayamashi, Tokyo, Japan.
出版信息
Nihon Hansenbyo Gakkai Zasshi. 2004 Sep;73(3):221-6. doi: 10.5025/hansen.73.221.
The relation between diaminodiphenylsulfone (called dapsone)-resistance and point mutations of the dihydropteroate synthase (DHPS) gene was analyzed using dapsone resistant Mycobacterium leprae isolates derived from Japanese leprosy patients. The mutation was found at amino acid residues 53 or 55 of the DHPS. This finding suggests that two specific mutations in the DHPS gene involved in dapsone resistance of M. leprae.
利用从日本麻风病患者分离出的耐氨苯砜麻风分枝杆菌菌株，分析了二氨基二苯砜（称为氨苯砜）耐药性与二氢蝶酸合酶（DHPS）基因点突变之间的关系。在DHPS的氨基酸残基53或55处发现了该突变。这一发现表明，DHPS基因中的两个特定突变与麻风分枝杆菌的氨苯砜耐药性有关。
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