Kai M, Matsuoka M, Nakata N, Maeda S, Gidoh M, Maeda Y, Hashimoto K, Kobayashi K, Kashiwabara Y
Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
FEMS Microbiol Lett. 1999 Aug 15;177(2):231-5. doi: 10.1111/j.1574-6968.1999.tb13737.x.
The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions.
对六种耐二氨基二苯砜麻风分枝杆菌菌株的二氢蝶酸合酶（DHPS）基因进行的核苷酸序列分析表明，突变局限于高度保守的氨基酸残基53或55处。虽然在其他细菌中已报道过氨基酸残基55或其同源位点的突变，但残基53处的突变在细菌中属首例。这是首篇将麻风分枝杆菌中DHPS突变与磺胺耐药性联系起来的论文。这一发现具有医学和社会意义，因为麻风病在某些地区仍是一个重大问题。
