Influence of amorolfine on the morphology of Candida albicans and Trichophyton mentagrophytes.

Amorolfine applied in concentrations of 0.1-100 micrograms/ml causes considerable damage to the ultrastructure of Candida albicans and Trichophyton mentagrophytes: electron-lucent areas appear in the cytoplasm. Extracytoplasmic membrane vesicles are formed and deposited in the cell wall. Starved fungal cells, with normal ultrastructure, can be found. Lysed, dead cells demonstrate the process of severe ultrastructural damage. T. mentagrophytes cell walls especially increase in thickness. The feature of the damage caused by amorolfine is comparable to that produced by azole antifungals.