Kinnari Teemu J, Rihkanen Heikki, Laine Timo, Salonen Eeva-Marjatta, Jero Jussi
Department of Otolaryngology, Helsinki University Central Hospital and the Haartman Institute, Helsinki, Finland.
Laryngoscope. 2004 Nov;114(11):2038-43. doi: 10.1097/01.mlg.0000147944.20676.17.
Coating an implant with albumin prevents adhesion of proteins, bacteria, and platelets and thus may lead to its improved and prolonged function. Previously, we have demonstrated the inhibition of binding of fibronectin, one of the most adhesive glycoproteins, on human serum albumin (HSA)-coated tympanostomy tubes and the durability of this binding inhibition in a 8-month trial. We have also demonstrated that the HSA coating inhibits the binding of Staphylococcus aureus and Pseudomonas aeruginosa to titanium plates. This prospective study evaluated the effect of albumin coating on tympanostomy tube sequelae and on the outcome of tympanostomized patients.
Double-blind, prospective, randomized clinical trial.
Two otolaryngological centers in southern Finland enrolled 179 pediatric patients. Number of tube occlusions and otorrhea and tube ventilation time in the ears with HSA-coated titanium tympanostomy tubes were compared with the contralateral ear with its uncoated, otherwise identical titanium tube during a 9-month follow-up period.
In HSA-coated tubes, average ventilation time was slightly longer and the number of early tube occlusions significantly less (P < .05). Moreover, in patients with perioperative bleeding, the coating prolonged average ventilation time of tympanostomy tubes significantly (P < .05).
HSA coating reduces early tube occlusions by preventing adherence of blood and secretion.
用白蛋白包被植入物可防止蛋白质、细菌和血小板的黏附，从而可能改善其功能并延长其使用寿命。此前，我们已证明在人血清白蛋白（HSA）包被的鼓膜造孔管上，可抑制纤维连接蛋白（最具黏附性的糖蛋白之一）的结合，并且在一项为期8个月的试验中证明了这种结合抑制的持久性。我们还证明了HSA包被可抑制金黄色葡萄球菌和铜绿假单胞菌与钛板的结合。这项前瞻性研究评估了白蛋白包被对鼓膜造孔管后遗症以及鼓膜造孔术患者预后的影响。
双盲、前瞻性、随机临床试验。
芬兰南部的两个耳鼻喉科中心招募了179名儿科患者。在9个月的随访期内，比较了HSA包被的钛质鼓膜造孔管所在耳的管堵塞和耳漏数量以及管通气时间，与对侧耳中未包被但其他方面相同的钛管进行对比。
在HSA包被的管中，平均通气时间略长，早期管堵塞的数量显著减少（P < .05）。此外，对于围手术期出血的患者，包被显著延长了鼓膜造孔管的平均通气时间（P < .05）。
HSA包被通过防止血液和分泌物的黏附减少早期管堵塞。
