Nakamura Katsumasa, Teshima Teruki, Takahashi Yutaka, Imai Atsushi, Koizumi Masahiko, Mitsuhashi Norio, Shioyama Yoshiyuki, Inoue Toshihiko
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Anticancer Res. 2004 Sep-Oct;24(5B):3141-5.
The role of radiotherapy for patients with localized hormone-refractory cancer has not been well documented.
The Patterns of Care Study in Japan examined the records of 311 patients with prostate cancer treated with radiotherapy during the period 1996--1998. Of them, 61 patients (19.6%) with regionally localized hormone-refractory cancer were selected. Local progression or biochemical failure was observed after a median duration of 15.9 months of androgen deprivation. At the time of radiotherapy, 49 patients (80.4%) had T3-4 tumors and 15 (26.8%) had regional lymph node metastases. External beam radiotherapy was performed with a median total dose of 60 Gy.
Although distant metastases or regional lymph node metastases were seen in 22 patients (36.1), local progression was observed in one patient (1.6%). The five-year overall and progression-free survival rates were 51.6% and 43.5%, respectively.
Radiotherapy had an excellent local control rate for hormone-refractory cancer.
放射治疗在局部激素难治性癌症患者中的作用尚未得到充分记录。
日本的治疗模式研究调查了1996年至1998年期间接受放射治疗的311例前列腺癌患者的记录。其中，选择了61例（19.6%）区域局限性激素难治性癌症患者。在雄激素剥夺中位持续时间15.9个月后观察到局部进展或生化失败。在放疗时，49例（80.4%）患者有T3-4期肿瘤，15例（26.8%）有区域淋巴结转移。外照射放疗的中位总剂量为60 Gy。
尽管22例患者（36.1%）出现远处转移或区域淋巴结转移，但仅1例患者（1.6%）观察到局部进展。五年总生存率和无进展生存率分别为51.6%和43.5%。
放射治疗对激素难治性癌症具有出色的局部控制率。
