日本局部激素难治性前列腺癌的放射治疗
Radiotherapy for localized hormone-refractory prostate cancer in Japan.
作者信息
Nakamura Katsumasa, Teshima Teruki, Takahashi Yutaka, Imai Atsushi, Koizumi Masahiko, Mitsuhashi Norio, Shioyama Yoshiyuki, Inoue Toshihiko
机构信息
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
出版信息
Anticancer Res. 2004 Sep-Oct;24(5B):3141-5.
BACKGROUND
The role of radiotherapy for patients with localized hormone-refractory cancer has not been well documented.
MATERIALS AND METHODS
The Patterns of Care Study in Japan examined the records of 311 patients with prostate cancer treated with radiotherapy during the period 1996--1998. Of them, 61 patients (19.6%) with regionally localized hormone-refractory cancer were selected. Local progression or biochemical failure was observed after a median duration of 15.9 months of androgen deprivation. At the time of radiotherapy, 49 patients (80.4%) had T3-4 tumors and 15 (26.8%) had regional lymph node metastases. External beam radiotherapy was performed with a median total dose of 60 Gy.
RESULTS
Although distant metastases or regional lymph node metastases were seen in 22 patients (36.1), local progression was observed in one patient (1.6%). The five-year overall and progression-free survival rates were 51.6% and 43.5%, respectively.
CONCLUSION
Radiotherapy had an excellent local control rate for hormone-refractory cancer.
背景
放射治疗在局部激素难治性癌症患者中的作用尚未得到充分记录。
材料与方法
日本的治疗模式研究调查了1996年至1998年期间接受放射治疗的311例前列腺癌患者的记录。其中，选择了61例（19.6%）区域局限性激素难治性癌症患者。在雄激素剥夺中位持续时间15.9个月后观察到局部进展或生化失败。在放疗时，49例（80.4%）患者有T3-4期肿瘤，15例（26.8%）有区域淋巴结转移。外照射放疗的中位总剂量为60 Gy。
结果
尽管22例患者（36.1%）出现远处转移或区域淋巴结转移，但仅1例患者（1.6%）观察到局部进展。五年总生存率和无进展生存率分别为51.6%和43.5%。
结论
放射治疗对激素难治性癌症具有出色的局部控制率。
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