Cylwik Bogdan, Chrostek Lech, Szmitkowski Maciej
Zakład Diagnostyki Biochemicznej AM w Białymstoku.
Pol Merkur Lekarski. 2004 Jun;16(96):581-4.
Alcoholism is one of the most frequent addictions among people. The early identification of alcohol abuse could increase the possibility of a favorable treatment outcome and reduce health care costs. Many biochemical laboratory markers of alcohol abuse have been used for several years, but each of them has clinical limitations. Recently, sialic acid (SA) has been suggested as a new potential marker of excessive alcohol consumption. In this paper, the general characteristic of SA has been given including the usefulness in the identifying of alcohol abuse. The clinical studies showed that serum and saliva sialic acid concentration was significantly higher in female and male alcoholics compared to social drinkers. It has been established also, that the serum SA level in male alcoholics was significantly increased after a short period of relapse to heavy alcohol drinking. In addition, the serum SA level was significantly decreased during an alcoholism treatment and abstinence. Sialic acid seems to be interesting biochemical marker of alcohol abuse (detecting, monitoring) with the diagnostic efficiency as good as, or even better, than the traditional markers used today.
酗酒是人群中最常见的成瘾问题之一。早期识别酒精滥用可提高获得良好治疗效果的可能性，并降低医疗保健成本。许多酒精滥用的生化实验室标志物已使用多年，但每种标志物都有临床局限性。最近，唾液酸（SA）被认为是过量饮酒的一种新的潜在标志物。本文介绍了唾液酸的一般特性，包括其在识别酒精滥用方面的用途。临床研究表明，与社交饮酒者相比，男性和女性酗酒者的血清和唾液唾液酸浓度显著更高。还已证实，男性酗酒者在短期重新大量饮酒后，血清SA水平显著升高。此外，在酒精中毒治疗和戒酒期间，血清SA水平显著降低。唾液酸似乎是一种有趣的酒精滥用生化标志物（用于检测、监测），其诊断效率与当今使用的传统标志物相当，甚至更好。
