Stojanović Radan, Todorović Zoran, Vucković Sonja, Nesić Zorica, Prostran Milica
Med Pregl. 2003;56 Suppl 1:13-7.
All three isoforms of nitric oxide synthase (NOS) are identified within various tissues of the respiratory system.
Under physiological conditions, small amounts of NO, produced by constitutive isoforms of NOS, appear to be important in regulation of basal pulmonary vascular tone and in mediating transition from fetal to neonatal circulation; also, NO exerts antiinflammatory actions, and modulates the respiratory smooth muscle tone. NO AND RESPIRATORY TRACT DISEASES: Under pathological conditions, inducible NOS-derived NO may produce lung damage. In addition, increased or decreased production of NO is found in chronic obstructive pulmonary disease, cystic fibrosis, asthma and related inflammatory disorders, and exhaled NO level measurement is a useful tool in diagnostics of respiratory disorders.
It has been shown that NO modulates contractility of the isolated diaphragm, and there are important interactions between NOS inhibitors and drugs for respiratory disorders (e.g. aminophylline).
一氧化氮合酶（NOS）的三种同工型在呼吸系统的各种组织中均有发现。
NOS同工型：在生理条件下，组成型NOS同工型产生的少量一氧化氮（NO）似乎在调节基础肺血管张力以及介导从胎儿循环到新生儿循环的转变中起重要作用；此外，NO具有抗炎作用，并调节呼吸平滑肌张力。
NO与呼吸道疾病：在病理条件下，诱导型NOS衍生的NO可能会导致肺损伤。此外，在慢性阻塞性肺疾病、囊性纤维化、哮喘及相关炎症性疾病中发现NO的产生增加或减少，呼出NO水平测量是诊断呼吸系统疾病的有用工具。
已表明NO可调节离体膈肌的收缩力，并且NOS抑制剂与治疗呼吸系统疾病的药物（如氨茶碱）之间存在重要相互作用。
