Bustamante Maldonado E, Marí Alfonso B, Monteagudo Jiménez M, Casanovas Martínez A, Jordana Comajuncosa R, Tolosa Vilella C, Oristrell Salvá J
Servicio de Medicina Interna, Corporació Sanitaria Parc Taul, Instituto Universitario Parc Taulí, UAB, Barcelona, Spain.
An Med Interna. 2004 Oct;21(10):473-6. doi: 10.4321/s0212-71992004001000002.
Our main aim with this study is to establish the epidemiologic and clinical features, treatment response and complications of a group composed of 55 patients with biopsy proven temporal arteritis in a local hospital.
Retrospective study based on clinical records revision of patients diagnosed of giant cell arteritis (GCA) made by temporal artery biopsy between 1989 and 2001.
The approximated annual incidence of GCA in our area is 4.1 cases per 100,000 persons over the age of 50. The mean age at diagnostic was 74 years and the 78,2% were women. The most common symptom at diagnostic was headache (81.5%) followed by systemic manifestations (74.1%) and later we found jaw claudication (32,7%), visual impairment (30.2%), isquemic manifestations (17%). Polymyalgia rheumatica was associated to GCA in 49.1% of cases. The temporal artery explorations was abnormal in the 76.9% of patients. The mean initial dose of corticoids was 69 mg prednisone per day, with a half dose reduction time of .5 months. In spite of that, 24,1% of patients relapsed during the first year. The 38% of patients did some complications during the corticosteroid treatment. The ESR was lower 50 mm in 12.7% of patients; it was anaemia in the 37.7% and thrombocytosis in 32,1%. In these last patients we detected a relation between thrombocytosis and specific visual impairment.
The incidence of GCA in our area is low. The results of our series aren't different from others publicated before in clinical manifestations, there is a prevalence of female sex and there is a relation between specific visual impairment and the presence of thrombocytosis.
本研究的主要目的是确定一家当地医院中55例经活检证实为颞动脉炎患者的流行病学和临床特征、治疗反应及并发症。
基于对1989年至2001年间经颞动脉活检诊断为巨细胞动脉炎（GCA）患者的临床记录进行回顾性研究。
我们地区50岁以上人群中GCA的年发病率约为每10万人4.1例。诊断时的平均年龄为74岁，78.2%为女性。诊断时最常见的症状是头痛（81.5%），其次是全身表现（74.1%），随后发现颌跛行（32.7%）、视力损害（30.2%）、缺血表现（17%）。49.1%的病例中风湿性多肌痛与GCA相关。76.9%的患者颞动脉检查异常。皮质类固醇的平均初始剂量为每天69毫克泼尼松，半量减少时间为0.5个月。尽管如此，24.1%的患者在第一年复发。38%的患者在皮质类固醇治疗期间出现了一些并发症。12.7%的患者红细胞沉降率低于50毫米；37.7%有贫血，32.1%有血小板增多。在这些最后的患者中，我们检测到血小板增多与特定视力损害之间存在关联。
我们地区GCA的发病率较低。我们系列研究的结果在临床表现方面与之前发表的其他研究结果没有差异，女性患病率较高，特定视力损害与血小板增多之间存在关联。
