Blankfield Robert P, Ahmed Mansoor, Zyzanski Stephen J
Department of Family Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Sleep Med. 2004 Nov;5(6):589-92. doi: 10.1016/j.sleep.2004.06.008.
Previous research has identified an association between idiopathic edema and obstructive sleep apnea (OSA) in women, but a causal relationship between OSA and edema has not been established. This study was undertaken to determine whether nasal continuous positive airway pressure (CPAP) lessens edema in patients with idiopathic edema and OSA.
This was a case-series study that enrolled eight ambulatory, obese, adults with bilateral, pitting pre-tibial edema and OSA from an inner city family practice and a suburban family practice from July 1995 until March 2003. Enrollees underwent subjective and physical examination assessment of changes in edema after initiation of nasal CPAP.
All but one of the subjects had severe OSA. The edema was typically 1+ to 2+, and the duration of the edema ranged from 6 months to more than 20 years. Seven of the eight subjects experienced a reduction in the amount of edema following nasal CPAP (P=0.04).
In subjects with OSA and idiopathic edema, nasal CPAP reduces the amount of edema. If valid, these results indicate that OSA can cause edema.
先前的研究已确定特发性水肿与女性阻塞性睡眠呼吸暂停（OSA）之间存在关联，但OSA与水肿之间的因果关系尚未确立。本研究旨在确定经鼻持续气道正压通气（CPAP）是否能减轻特发性水肿合并OSA患者的水肿。
这是一项病例系列研究，从1995年7月至2003年3月，纳入了来自市中心家庭诊所和郊区家庭诊所的8名非卧床、肥胖、患有双侧胫前凹陷性水肿和OSA的成年人。参与者在开始经鼻CPAP治疗后接受了水肿变化的主观和体格检查评估。
除一名受试者外，所有受试者均患有严重OSA。水肿通常为1+至2+，水肿持续时间从6个月到20多年不等。8名受试者中有7名在接受经鼻CPAP治疗后水肿量减少（P=0.04）。
在患有OSA和特发性水肿的受试者中，经鼻CPAP可减少水肿量。如果这些结果有效，则表明OSA可导致水肿。
