Wade J R, Kelman A W, Kerr D J, Robert J, Whiting B
Department of Medicine and Therapeutics, University of Glasgow, Gardiner Institute, Western Infirmary, UK.
Cancer Chemother Pharmacol. 1992;29(5):391-5. doi: 10.1007/BF00686009.
Population pharmacokinetic analysis of the anticancer agent epirubicin was carried out using the program NONMEM. Data were available from 36 patients aged 20-73 years, of whom 23 were women. All subjects exhibited normal liver and renal function. Epirubicin was given as a short-term i.v. infusion over the dose range of 25-100 mg/m2, and an average of 11 plasma samples/subject were taken for a period of up to 72 h after each dose. A Two compartment model was fitted to the data, characterised by the parameters clearance, volume of the central compartment, alpha and beta. Clearance was tested as a linear function of various demographic and/or biochemical features. A significant proportion of the variability in clearance could be attributed to sex, and also to age in women. For example, a 25-year-old man would display an average clearance of 95 l/h, whereas a 70-year-old woman would exhibit an average clearance of 64 l/h. Such differences in clearance might be important in the selection of epirubicin dose regimens.
使用NONMEM程序对抗癌药物表柔比星进行群体药代动力学分析。数据来自36名年龄在20至73岁之间的患者，其中23名是女性。所有受试者的肝肾功能均正常。表柔比星以25至100 mg/m²的剂量范围进行短期静脉输注，每次给药后在长达72小时的时间内，平均每名受试者采集11份血浆样本。对数据拟合了二室模型，其特征参数为清除率、中央室容积、α和β。将清除率作为各种人口统计学和/或生化特征的线性函数进行检验。清除率变异性的很大一部分可归因于性别，在女性中还可归因于年龄。例如，一名25岁的男性平均清除率为95 l/h，而一名70岁的女性平均清除率为64 l/h。这种清除率的差异在表柔比星给药方案的选择中可能很重要。
