Mahomed K, Williams M A, Woelk G B, Jenkins-Woelk L, Mudzamiri S, Madzime S, Sorensen T K
Department of Obstetrics and Gynaecology, University of Zimbabwe, School of Medicine, Harare.
J Obstet Gynaecol. 1998 May;18(3):218-22. doi: 10.1080/01443619867344.
We sought to estimate the risk of recurrence of preeclampsia-eclampsia among Zimbabwean women. Additionally, we sought to assess the extent to which family history of pregnancy-induced or chronic hypertension was predicative of the risk of developing preeclampsia-eclampsia. This hospital based case-control study was conducted at Harare Maternity Hospital, Harare Zimbabwe during the period June 1995 to April 1996. Study participants were 200 women with preeclampsia or eclampsia and 200 normotensive pregnant women serving as controls. Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Among multiparous women, a history of any pregnancy-induced hypertension was associated with a 10.5-fold increase in risk of preeclampsia-eclampsia in a subsequent pregnancy (95% CI 4.7-23.5). Women who reported that their mother or sisters experienced pregnancy-induced hypertension were found to be at an increased risk of preeclampsia-eclampsia (OR = 2.3 and 2.6, respectively). A 2.3-fold excess risk of preeclampsia-eclampsia was associated with paturients' maternal history of chronic hypertension (95% CI 1.3-3.6). The corresponding relative risk of preeclampsia-eclampsia for women reporting to have a sister with chronic hypertension was 2.6 (95% CI 1.2-5.3). Zimbabwean women, like North American and European women, are at increased risk for the recurrence of preeclampsia-eclampsia. Findings from our study and those of others suggest a possible genetic component involved in the multifactorial aetiology of preeclampsia-eclampsia. The information provided here should be useful to clinicians involved in the management of patients with a prior history or family history of hypertension.
我们试图估算津巴布韦女性先兆子痫-子痫复发的风险。此外，我们还试图评估妊娠相关性高血压或慢性高血压家族史对发生先兆子痫-子痫风险的预测程度。这项基于医院的病例对照研究于1995年6月至1996年4月在津巴布韦哈拉雷市的哈拉雷妇产医院进行。研究对象为200例患有先兆子痫或子痫的女性以及200例血压正常的孕妇作为对照。采用逻辑回归程序估算比值比（OR）和95%置信区间（CI）。在经产妇中，任何妊娠相关性高血压病史与后续妊娠中先兆子痫-子痫风险增加10.5倍相关（95%CI 4.7-23.5）。报告其母亲或姐妹曾患妊娠相关性高血压的女性发生先兆子痫-子痫的风险增加（OR分别为2.3和2.6）。先兆子痫-子痫风险增加2.3倍与患者母亲的慢性高血压病史相关（95%CI 1.3-3.6）。报告有姐妹患慢性高血压的女性发生先兆子痫-子痫的相应相对风险为2.6（95%CI 1.2-5.3）。与北美和欧洲女性一样，津巴布韦女性先兆子痫-子痫复发的风险增加。我们的研究结果以及其他研究结果表明，先兆子痫-子痫多因素病因中可能涉及遗传因素。此处提供的信息应有助于参与管理有高血压病史或家族史患者的临床医生。
