Bradley Walter G
Department of Neurology, University of Miami School of Medicine, Florida, USA.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep;5 Suppl 1:137-40. doi: 10.1080/17434470410019708.
The time is now ripe for the ALS community in the United States to set up a national ALS Study Group. NIH and other granting agencies should fund a program to set up and run the ALS Study Group for five years renewable. This program should result in a competitive request for applications. The benefits likely to derive from a national ALS Study Group would include cheaper and more cost-effective clinical therapeutic trials, the development of better techniques for pilot trials, an increased number of potential new drugs brought from bench to bedside for ALS trials, increased research on biological and surrogate markers of disease, and increased physician-initiated research.
现在，美国肌萎缩侧索硬化症（ALS）群体成立一个全国性ALS研究小组的时机已经成熟。美国国立卫生研究院（NIH）和其他资助机构应资助一个项目，以设立并运营ALS研究小组，为期五年，可续签。该项目应产生一份具有竞争力的申请要求。一个全国性ALS研究小组可能带来的益处包括开展更廉价且更具成本效益的临床治疗试验、开发更好的试点试验技术、增加从实验室带到临床用于ALS试验的潜在新药数量、加强对疾病生物学和替代标志物的研究，以及增加医生发起的研究。
