Amiodarone optic neuropathy--review.

The antiarrhythmic agent, amiodarone (Cordone), Pacerone), has been reported to cause optic neuropathy. However, the clinical manifestations are similar to non-arteritic anterior ischemic optic neuropathy (AION), which makes diagnosing amiodarone optic neuropathy difficult. There is controversy whether or not amiodarone optic neuropathy actually exists as a distinct entity. The clinical manifestations and the proposed pathophysiology of amiodarone optic neuropathy are discussed.