Gruener Gregory, Jay Walter
Department of Neurology, Loyola University Medical Center, Maywood, IL 60153, USA.
Semin Ophthalmol. 2003 Dec;18(4):200-4. doi: 10.1080/08820530390895208.
Botulinum toxin has been increasingly applied to the treatment of a wide variety of neurological disorders. Its application to headache disorders, and specifically those classified as migraine or tension-type, followed the observation of its effectiveness in decreasing pain. Studies that have primarily used botulinum toxin type A, but with varying dose regimens and sites of administration, have since observed its beneficial effects and in those subjects, headaches have lessened in their frequency or severity. However, questions that have primarily concerned dose and sites of administration have since arisen and clear guidelines for botulinum toxin use in headache disorders have yet to be developed.
肉毒杆菌毒素已越来越多地应用于多种神经系统疾病的治疗。它在头痛疾病，特别是归类为偏头痛或紧张型头痛的疾病中的应用，是在观察到其在减轻疼痛方面的有效性之后。主要使用A型肉毒杆菌毒素，但给药方案和给药部位各不相同的研究，此后观察到了其有益效果，在这些受试者中，头痛的频率或严重程度有所减轻。然而，此后出现了主要涉及剂量和给药部位的问题，用于头痛疾病的肉毒杆菌毒素使用的明确指南尚未制定。
