Manfredi Roberto, Dentale Nicola, Fortunato Lorenza, Pavoni Michele, Calza Leonardo, Chiodo Francesco
Department of Clinical and Experimental Medicine, University of Bologna "Alma Mater Studiorum", S. Orsola Hospital, Bologna, Italy.
Scand J Infect Dis. 2004;36(10):756-8. doi: 10.1080/00365540410021045.
Common variable immunodeficiency with an associated broad immunoglobulin (0.7%) deficit affecting all subclasses, was revealed in a 27-y-old previously healthy female, upon development of a severe pneumococcal meningitis. We report the third case of purulent meningitis complicating this primary immunodeficiency, and the second due to Streptococcus pneumoniae. Clinicians should maintain an elevated suspicion for congenital immunodeficiency, especially when observing adult patients with a negligible prior history.
一名27岁既往健康的女性在发生严重肺炎球菌性脑膜炎后，被发现患有常见变异型免疫缺陷，伴有影响所有亚类的广泛免疫球蛋白（0.7%）缺乏。我们报告了第三例并发这种原发性免疫缺陷的化脓性脑膜炎病例，也是第二例由肺炎链球菌引起的病例。临床医生应高度怀疑先天性免疫缺陷，尤其是在观察既往病史可忽略不计的成年患者时。
