Cold adaptation modulates Ca2+ signaling in brown preadipocytes.
作者信息
Baumuratov A S, Abzhalelov B B, Kramarova L I, Dolgacheva L P, Zinchenko V P, Bronnikov G E
机构信息
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
出版信息
Bull Exp Biol Med. 2004 Jul;138(1):50-3. doi: 10.1023/b:bebm.0000046937.88720.89.
Abstract
One-week cold exposure of mice led to a 2-fold increase in the density of alpha1-adrenoceptors in brown adipose tissue. The density of alpha1-adrenoceptors returned to normal after adaptation to cold for 2 weeks. The reduced Ca2+ signaling in stem cells of brown fat activated via beta-adrenoceptors and cAMP was transformed into the Ca2+-system induced by alpha1-adrenoceptors and similar to that in mature brown adipocytes.
摘要
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