Zarubina I V, Kuritsyna N A, Shabanov P D
Department of Pharmacology, S. M. Kirov Military Medical Academy, Russian Ministry of Defense, St. Petersburg.
Bull Exp Biol Med. 2004 Jul;138(1):58-62. doi: 10.1023/b:bebm.0000046939.59393.ac.
Monotherapy of consequences of craniocerebral trauma with pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemitil in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemitil was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemitil had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.
用吡拉西坦（1毫克/千克）对颅脑创伤后果进行单一疗法，对高度耐缺氧动物产生抗焦虑作用，对低耐缺氧动物产生激活作用。以25毫克/千克的剂量使用贝美蒂尔进行治疗，对高耐受力和低耐受力大鼠的大脑产生了脑保护作用，并使个体行为特征、能量代谢参数和抗氧化系统状态恢复正常。贝美蒂尔的作用在高度耐受力动物中最为明显。在联合治疗期间，吡拉西坦和贝美蒂尔在两组动物中均具有相加作用。它们使行为反应恢复正常，并防止大脑中代谢紊乱的发生。
