联萘酚催化苯乙炔基钛对芳族酮的对映选择性加成反应。
BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones.
作者信息
Cozzi Pier Giorgio, Alesi Silvia
机构信息
Dipartimento di Chimica G. Ciamician, Via Selmi 2, 40126, Bologna, Italy.
出版信息
Chem Commun (Camb). 2004 Nov 7(21):2448-9. doi: 10.1039/b408654f. Epub 2004 Sep 21.
DOI:10.1039/b408654f
PMID:15514809
Abstract
An enantioselective addition of titanium phenylacetylide to ketones, promoted by BINOL, is described; this new enantioselective protocol gives high enantiomeric excess (up to 90% ee) with aromatic ketones using a simple procedure without pyrophoric or expensive reagents.
摘要
描述了一种由联萘酚（BINOL）促进的苯乙炔基钛对酮的对映选择性加成反应；这种新的对映选择性方法通过简单的步骤，在不使用引火或昂贵试剂的情况下，对于芳香酮能给出高对映体过量（高达90% ee）。
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