首例串联双钯催化胺化反应：二吡啶并[1,2-a:3',2'-d]咪唑及其苯并和氮杂类似物的合成
The first tandem double palladium-catalyzed aminations: synthesis of dipyrido[1,2-a:3',2'-d]imidazole and its benzo- and aza-analogues.
作者信息
Loones Kristof T J, Maes Bert U W, Dommisse Roger A, Lemière Guy L F
机构信息
Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020, Antwerp, Belgium.
出版信息
Chem Commun (Camb). 2004 Nov 7(21):2466-7. doi: 10.1039/b409161b. Epub 2004 Sep 20.
DOI:10.1039/b409161b
PMID:15514818
Abstract
A new strategy for the synthesis of the title compounds via a regio- and chemoselective one-pot inter- and intramolecular Buchwald-Hartwig amination of 2-chloro-3-iodopyridine with aminoazines and -diazines is reported.
摘要
报道了一种通过2-氯-3-碘吡啶与氨基嗪和二嗪进行区域和化学选择性的一锅法分子间和分子内布赫瓦尔德-哈特维希胺化反应来合成标题化合物的新策略。
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