Benveniste Olivier, Herson Serge, Salomon Benoît, Dimitri Dalia, Trébeden-Nègre Hélène, Jean Laetitia, Bon-Durand Véronique, Antonelli David, Klatzmann David, Boyer Olivier
Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris, France.
Ann Neurol. 2004 Dec;56(6):867-72. doi: 10.1002/ana.20293.
Polymyositis is a CD8(+) T-cell-mediated disease. T-cell clonal expansions are observed at disease onset, but little is known about their persistence over time. Qualitative and quantitative spectratyping demonstrated that PM relapse features dramatically perturbed blood T-cell repertoires but is not associated with the emergence of new T-cell clones. It is striking that patients in remission also maintained all their T-cell repertoire abnormalities. The clonally expanded T-cells displayed a memory phenotype, expressed intracellular perforin, and dramatically responded to IL-2, showing a potential to be reactivated upon appropriate conditions. These results indicate that persistent T-cell clonal expansion is an important feature of polymyositis.
多发性肌炎是一种由CD8(+) T细胞介导的疾病。在疾病发作时可观察到T细胞克隆性扩增，但对其随时间的持续性了解甚少。定性和定量光谱分型表明，多发性肌炎复发的特征是血液T细胞库显著紊乱，但与新T细胞克隆的出现无关。令人惊讶的是，缓解期患者也维持了所有T细胞库异常。克隆性扩增的T细胞表现出记忆表型，表达细胞内穿孔素，并对白细胞介素-2有显著反应，表明在适当条件下有重新激活的潜力。这些结果表明，持续性T细胞克隆性扩增是多发性肌炎的一个重要特征。
