Bulk Saskia, Visser Otto, Rozendaal Lawrence, Verheijen René H M, Meijer Chris J L M
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Int J Cancer. 2005 Mar 1;113(6):1005-9. doi: 10.1002/ijc.20678.
Cervical cancer is a preventable disease, occurring in relatively young women. In the Netherlands, population-based cervical screening aims at women aged 30-60 years. We performed a population-based study of the incidence of invasive cervical cancer in the Netherlands to evaluate trends, with emphasis on age at time of diagnosis. Histologic diagnosis was retrieved from the Netherlands Cancer Registry for all women residing in the Netherlands with invasive cervical cancer between January 1, 1989, and December 31, 1998. In this 10-year period, the incidence rate of squamous cell carcinoma decreased significantly from 7.1/100,000 to 6.1/100,000 (p < 0.001), with the greatest decrease in women aged 60-74 (-5.5%). While the overall incidence rate of adenocarcinoma remained stable, it increased in women aged 15-29 (+15.8%) and in women aged 30-44 (+2.5%), though the number of cases was small. For squamous cell carcinoma, the incidence of stage II at diagnosis decreased most (-2.7%). There was no change in stage at diagnosis for adenocarcinoma. Most cases of cervical cancer, 60.5%, were detected between ages 30 and 60 years, i.e., the Dutch screening age interval. Cervical cancer in women below age 30 contributed 5.0% to the total incidence, with 3.0% occurring between ages 27 and 29. Thus, screening for cervical cancer in the Netherlands is associated with a decrease in the incidence of squamous cell carcinoma and adenocarcinoma incidence appears to be increasing in younger women.
宫颈癌是一种可预防的疾病，多见于相对年轻的女性。在荷兰，基于人群的宫颈癌筛查目标人群为30至60岁的女性。我们对荷兰浸润性宫颈癌的发病率进行了一项基于人群的研究，以评估发病趋势，重点关注诊断时的年龄。从荷兰癌症登记处获取了1989年1月1日至1998年12月31日期间居住在荷兰的所有浸润性宫颈癌女性的组织学诊断信息。在这10年期间，鳞状细胞癌的发病率从7.1/10万显著下降至6.1/10万（p<0.001），60至74岁女性的下降幅度最大（-5.5%）。虽然腺癌的总体发病率保持稳定，但在15至29岁的女性中有所上升（+15.8%），在30至44岁的女性中也有所上升（+2.5%），不过病例数较少。对于鳞状细胞癌，诊断时II期的发病率下降最为明显（-2.7%）。腺癌诊断时的分期没有变化。大多数宫颈癌病例（60.5%）在30至60岁之间被检测到，即荷兰的筛查年龄区间。30岁以下女性的宫颈癌占总发病率的5.0%，其中27至29岁的占3.0%。因此，荷兰的宫颈癌筛查与鳞状细胞癌发病率的下降相关，而腺癌的发病率在年轻女性中似乎在上升。
