Markowska Joanna, Romaniuk Wanda, Kozioł Henryk
Z Katedry i Oddziału Klinicznego Chorób Oczu Slaskiej Akademii Medycznej w Katowicach Wojewódzki Szpital Specjalistyczny nr 5 im. Swietej Barbary w Sosnowcu.
Klin Oczna. 2004;106(3):312-7.
The aim of this study was to estimate HRT usefulness in quantitative evaluation of structural glaucomatous optic nerve head damage and in monitoring this atrophy in POAG patients and normal subjects, during 18-monthly follow up.
130 eyes of 84 patients with primary open angle glaucoma, 52 women (79 eyes) and 32 men (51 eyes) in age 45-70 (mean = 54.69 yrs) and 96 eyes of 48 normal subjects, 33 women (66 eyes) and 15 men (30 eyes) in age 40-70 (mean=51.90 yrs). The ONH-stereometric parameters were examined using confocal laser scanning tomography--HRT (version 2.01).
All of ONH stereometric parameters (except: HVC) statistically significant distinguish glaucoma and normal eyes. The most marked of ONH-parameters are: C/D area ratio, CA, CSM, RA, RV, Mean cup depth, CV, Max cup depth, Mean RNFL thickness, RNFL-csa and DA. Statistically significant changes of all ONH stereometric parameters in primary open angle glaucoma were found during follow up (except: HVC, CV and CSM).
HRT is precise method for ONH-parameters evaluation. All of ONH-stereometric parameters (except HVC) are good markers of quantitative ONH-glaucomatous damage. HRT is valuable and precise method of quantitative monitoring progression of glaucomatous neuropathy.
本研究旨在评估在为期18个月的随访期间,高分辨率视网膜断层扫描(HRT)在定量评估青光眼性视神经乳头结构损伤以及监测原发性开角型青光眼(POAG)患者和正常受试者的视神经萎缩方面的效用。
84例原发性开角型青光眼患者的130只眼,其中52名女性(79只眼)和32名男性(51只眼),年龄在45 - 70岁(平均54.69岁);48名正常受试者的96只眼,其中33名女性(66只眼)和15名男性(30只眼),年龄在40 - 70岁(平均51.90岁)。使用共焦激光扫描断层扫描——HRT(版本2.01)检查视神经乳头立体测量参数。
所有视神经乳头立体测量参数(除高海拔视杯区[HVC]外)在统计学上都能显著区分青光眼眼和正常眼。最显著的视神经乳头参数有:杯盘面积比、视杯面积、视杯上半面积、视杯下半面积、视杯体积、平均视杯深度、视杯体积系数、最大视杯深度、平均视网膜神经纤维层厚度、视网膜神经纤维层横截面积和视盘面积。在随访期间发现原发性开角型青光眼所有视神经乳头立体测量参数(除HVC、视杯体积系数和视杯上半面积外)都有统计学上的显著变化。
HRT是评估视神经乳头参数的精确方法。所有视神经乳头立体测量参数(除HVC外)都是青光眼性视神经乳头定量损伤的良好指标。HRT是定量监测青光眼性神经病变进展的有价值且精确的方法。