Reinhart H H, Reinhart E, Korlipara P, Peleman R
Division of Infectious Diseases, Wayne State University, Detroit, Michigan.
Gastroenterology. 1992 Apr;102(4 Pt 1):1396-9.
Nitrofurantoin is an antibiotic commonly used for prophylaxis and treatment of urinary tract infections. Pulmonary and hepatic toxicity are rare side effects of this agent. The simultaneous occurrence of pulmonary fibrosis and chronic active hepatitis in a patient undergoing long-term nitrofurantoin therapy is reported. The presence of pulmonary toxicity was evidenced by infiltrates on chest radiographs and impaired diffusion capacity during pulmonary function tests. Prolonged elevation of liver enzyme concentrations together with the presence of increased antibody titers (anti-smooth muscle antibody, antinuclear antibody) was suggestive of chronic hepatitis, a diagnosis corroborated by liver biopsy findings. After discontinuation of nitrofurantoin therapy, the patient had a full recovery. The infiltrates initially found on chest radiographs disappeared, and laboratory parameters normalized without the need for corticosteroid therapy.
呋喃妥因是一种常用于预防和治疗尿路感染的抗生素。肺部和肝脏毒性是该药物罕见的副作用。本文报告了一名长期接受呋喃妥因治疗的患者同时出现肺纤维化和慢性活动性肝炎的病例。胸部X光片上的浸润影以及肺功能测试中弥散功能受损证明存在肺部毒性。肝酶浓度持续升高以及抗体滴度（抗平滑肌抗体、抗核抗体）增加提示慢性肝炎，肝脏活检结果证实了这一诊断。停用呋喃妥因治疗后，患者完全康复。最初在胸部X光片上发现的浸润影消失，实验室指标恢复正常，无需使用皮质类固醇治疗。
