Juhascik Matthew, Le Ngog Lan, Tomlinson Kimberly, Moore Christine, Gaensslen R E, Negrusz Adam
Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA.
J Anal Toxicol. 2004 Sep;28(6):400-6. doi: 10.1093/jat/28.6.400.
The objective of this study was to develop a screening process for the analysis of sexual assault samples. Recently, the Society of Forensic Toxicologists created a committee to address the issue of drug-facilitated sexual assault (DFSA) in the toxicology field. This committee prepared a list of drugs that could be, or have been, used in DFSAs. The list comprises about 50 compounds, including illicit, prescription, and over-the-counter drugs. Using this list, our laboratory wanted an easy, fast, and sensitive method to analyze a urine sample for all 50 of these drugs. We screened and confirmed for 20 compounds, including cocaine, amphetamines, benzodiazepines, barbiturates, opiates, methadone, alcohol, and PCP. A gas chromatographic-mass spectrometric screening method that was able to detect the remaining 30 compounds following 1 extraction and using only 2 mL of urine was developed. The process is inexpensive and uses equipment available in most forensic toxicology laboratories. This method is recommended for any laboratory that commonly receives specimens collected from sexual assault victims and is interested in a more thorough analysis.
本研究的目的是开发一种用于分析性侵犯样本的筛查方法。最近，法医毒理学家协会成立了一个委员会，以解决毒理学领域中药物辅助性侵犯（DFSA）的问题。该委员会编制了一份可能或已经用于DFSA的药物清单。该清单包括约50种化合物，包括非法药物、处方药和非处方药。利用这份清单，我们实验室想要一种简便、快速且灵敏的方法来分析尿液样本中的所有这50种药物。我们对20种化合物进行了筛查和确认，包括可卡因、苯丙胺、苯二氮䓬类、巴比妥类、阿片类、美沙酮、酒精和苯环己哌啶。开发了一种气相色谱-质谱筛查方法，该方法仅需1次萃取，仅使用2 mL尿液就能检测出其余30种化合物。该方法成本低廉，使用的是大多数法医毒理学实验室都有的设备。对于任何经常接收从性侵犯受害者采集的样本且希望进行更全面分析的实验室，推荐使用此方法。
