Rodacki M, Zajdenverg L, Albernaz M S, Bencke-Gonçalves M R, Milech A, Oliveira J E P
Serviço de Diabetes e Nutrologia, Universidade Federal do Rio de Janeiro, Brasil.
Braz J Med Biol Res. 2004 Nov;37(11):1645-50. doi: 10.1590/s0100-879x2004001100008. Epub 2004 Oct 26.
The objective of the present study was to determine whether the duration of disease has any influence on the prevalence of glutamic acid decarboxylase autoantibodies (GADA) in Brazilian patients with type 1 diabetes (T1D) and variable disease duration. We evaluated 83 patients with T1D. All participants were interviewed and blood was obtained for GADA measurement by a commercial radioimmunoassay (RSR Limited, Cardiff, UK). Four groups of patients were established according to disease duration: A) 1-5 years of disease (N = 24), B) 6-10 years of disease (N = 19), C) 11-15 years of disease (N = 25), and D) >15 years of disease (N = 15). GADA prevalence and its titers were determined in each group. GADA was positive in 38 patients (45.8%) and its frequency did not differ between the groups. The prevalence was 11/24 (45.8%), 8/19 (42.1%), 13/25 (52%), and 6/15 (40%) in groups A, B, C, and D, respectively (P = 0.874). Mean GADA titer was 12.54 +/- 11.33 U/ml for the sample as a whole and 11.95 +/- 11.8, 12.85 +/- 12.07, 10.57 +/- 8.35, and 17.45 +/- 16.1 U/ml for groups A, B, C, and D, respectively (P = 0.686). Sex, age at diagnosis or ethnic background had no significant effect on GADA (+) frequency. In conclusion, in this transversal study, duration of disease did not affect significantly the prevalence of GADA or its titers in patients with T1D after one year of diagnosis. This was the first study to report this finding in the Brazilian population.
本研究的目的是确定病程长短对巴西1型糖尿病（T1D）患者且病程各异的谷氨酸脱羧酶自身抗体（GADA）患病率是否有任何影响。我们评估了83例T1D患者。所有参与者均接受了访谈，并通过商业放射免疫测定法（RSR Limited，英国加的夫）采集血液以测量GADA。根据病程长短将患者分为四组：A）病程1 - 5年（N = 24），B）病程6 - 10年（N = 19），C）病程11 - 15年（N = 25），D）病程>15年（N = 15）。测定每组患者的GADA患病率及其滴度。38例患者（45.8%）GADA呈阳性，且各组之间其频率无差异。A、B、C、D组的患病率分别为11/24（45.8%）、8/19（42.1%）、13/25（52%）和6/15（40%）（P = 0.874）。整个样本的平均GADA滴度为12.54±11.33 U/ml，A、B、C、D组分别为11.95±11.8、12.85±12.07、10.57±8.35和17.45±16.1 U/ml（P = 0.686）。性别、诊断时年龄或种族背景对GADA阳性频率无显著影响。总之，在这项横断面研究中，病程长短对诊断一年后的T1D患者GADA患病率或其滴度无显著影响。这是首次在巴西人群中报告这一发现的研究。
