Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Nutrology Department, Rio de Janeiro/RJ, Brazil.
Clinics (Sao Paulo). 2013 Jan;68(1):123-6. doi: 10.6061/clinics/2013(01)rc02.
To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations.
Eighty-eight patients with a mean disease duration of 8.1 +7.6 years were included and underwent C-peptide measurement before and after glucagon stimulation. Chi-squared and Mann Whitney U-tests were used to compare the variables between groups (all two-tailed, α = 0.05). Spearmans correlation coefficient was used to test the association between the continuous variables. Logistic regression was used for the multivariate analysis. Twenty-eight (31.8%) individuals had significantly detectable C-peptide levels after stimuli, particularly those with a shorter disease duration (p<0.001).
Patients with detectable C-peptide levels required lower insulin doses (p<0.009) and had similar HbA1C results (p = 0.182) and fewer chronic complications (p = 0.029).
C-peptide detection was common in Type-1 diabetics, particularly shortly after being diagnosed. This result may have clinical implications.
评估来自多民族人群的 88 例 1 型糖尿病患者的血清 C 肽水平，这些患者的疾病持续时间不同。
共纳入 88 例平均病程为 8.1±7.6 年的患者，并在胰高血糖素刺激前后进行 C 肽测定。使用卡方检验和曼-惠特尼 U 检验比较组间的变量（均为双侧，α=0.05）。采用斯皮尔曼相关系数检验连续变量之间的相关性。采用多元逻辑回归进行多变量分析。28 例（31.8%）患者在刺激后可检测到明显的 C 肽水平，特别是那些病程较短的患者（p＜0.001）。
可检测到 C 肽水平的患者胰岛素剂量较低（p＜0.009），HbA1C 结果相似（p=0.182），慢性并发症较少（p=0.029）。
1 型糖尿病患者中 C 肽的检测较为常见，特别是在诊断后不久。这一结果可能具有临床意义。
