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[正电子发射断层显像/计算机断层扫描在放射治疗中的应用]

[PET/CT in radiotherapy].

作者信息

Weckesser M, Könemann S, Brinkmann M, Willich N, Schober O

机构信息

Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Münster.

出版信息

Radiologe. 2004 Nov;44(11):1096-104. doi: 10.1007/s00117-004-1124-7.

DOI:10.1007/s00117-004-1124-7
PMID:15517138
Abstract

Combining positron emission tomography (PET) and X-ray computed tomography (CT) with simultaneous acquisition may improve diagnostic accuracy in oncology. Moreover this combination holds considerable promise in radiotherapy. Metabolic information may be used in decision making in radiotherapy and in planning target volumes. Furthermore early evaluation of treatment efficacy becomes possible. New tracers for the assessment of tumour hypoxia or apoptosis in clinical routine are currently being developed. These tracers may yield high relevance in radiotherapy. Hybrid scanners facilitate patient handling and shorten the duration of acquisition. Furthermore fusion accuracy is optimal. Prospective studies have to be conducted to show that the new technology improves patient care in terms of efficiency and quality.

摘要

将正电子发射断层扫描(PET)与X射线计算机断层扫描(CT)同时采集相结合,可能会提高肿瘤学的诊断准确性。此外,这种组合在放射治疗方面也有很大的前景。代谢信息可用于放射治疗的决策制定和靶区体积规划。此外,还可以对治疗效果进行早期评估。目前正在开发用于临床常规评估肿瘤缺氧或凋亡的新型示踪剂。这些示踪剂在放射治疗中可能具有高度相关性。混合型扫描仪便于患者管理并缩短采集时间。此外,融合精度是最佳的。必须进行前瞻性研究,以证明这项新技术在效率和质量方面改善了患者护理。

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Lung Cancer. 2004 Aug;45 Suppl 2:S69-74. doi: 10.1016/j.lungcan.2004.07.990.
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Side-by-side reading of PET and CT scans in oncology: which patients might profit from integrated PET/CT?肿瘤学中PET与CT扫描的并行阅读:哪些患者可能从PET/CT一体化检查中获益?
Eur J Nucl Med Mol Imaging. 2004 Nov;31(11):1456-61. doi: 10.1007/s00259-004-1593-y. Epub 2004 Jul 10.
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Apoptosis-detecting radioligands: current state of the art and future perspectives.
凋亡检测放射性配体:现状与未来展望
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Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer.18F-氟脱氧葡萄糖正电子发射断层扫描对非小细胞肺癌放射治疗靶区勾画的影响
Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):78-86. doi: 10.1016/j.ijrobp.2003.10.044.
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2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography in target volume definition for radiotherapy of patients with non-small-cell lung cancer.2-脱氧-2-[¹⁸F]氟-D-葡萄糖正电子发射断层扫描在非小细胞肺癌患者放疗靶区定义中的应用
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Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study.正电子发射断层扫描与计算机断层扫描一体化(PET/CT)的放射治疗计划:一项可行性研究。
Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):853-63. doi: 10.1016/s0360-3016(03)00346-8.
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