Nagaike Ryoko, Sawaguchi Akira, Kawano Jun-ichi, Aoyama Fumiyo, Oinuma Tsutomu, Suganuma Tatsuo
Department of Anatomy, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, 889-1692 Miyazaki, Japan.
Virchows Arch. 2004 Dec;445(6):580-8. doi: 10.1007/s00428-004-1134-x. Epub 2004 Oct 28.
Gastric ulcers in humans are notoriously chronic and recurring lesions. Although the average individual who undergoes no treatments requires many years for healing, most studies on the healing process of the experimentally induced ulcers have mainly focused on the early stages. Natural history of the ulcer healing has not been completely revealed. We have undertaken long-term investigation up to the 150th day after the cryo-injury to shed light on the natural history of the ulcer healing process compared with developmental changes of postnatal fundic glands. By the 30th day, restitutive gastric glands were mostly seen to cover the ulcer lesions, where well-developed gland-type mucous cells, showing Griffonia simplicifolia agglutinin (GSA)-II labeling, appeared to occupy the basal portion. Most of the bromodeoxyuridine-labeled cells were superimposed on the GSA-II-positive cell zone, forming the proliferative zone. By the 150th day, the restitutive glands were complete, with all epithelial components and topology of the normal fundic glands. The process of the ulcer healing was quite compatible with the developmental changes of the postnatal fundic glands. These results imply that the regeneration of gastric epithelium during the ulcer healing follows pathways linked to the ontogenetic course of the fundic gland.
人类胃溃疡是出了名的慢性复发性病变。虽然未经治疗的普通个体需要数年时间才能愈合，但大多数关于实验性诱导溃疡愈合过程的研究主要集中在早期阶段。溃疡愈合的自然史尚未完全揭示。我们进行了长达150天的冷冻损伤后长期调查，以阐明溃疡愈合过程的自然史，并与出生后胃底腺的发育变化进行比较。到第30天时，大多可见修复性胃腺覆盖溃疡病变，其中显示有简单型灰叶豆凝集素（GSA）-II标记的发育良好的腺型黏液细胞似乎占据基部。大多数溴脱氧尿苷标记的细胞叠加在GSA-II阳性细胞区，形成增殖区。到第150天时，修复性腺体已完全形成，具有正常胃底腺的所有上皮成分和拓扑结构。溃疡愈合过程与出生后胃底腺的发育变化非常吻合。这些结果表明，溃疡愈合过程中胃上皮的再生遵循与胃底腺个体发生过程相关的途径。
