Mamełka Beata, Lobos Marek, Sass-Just Maria, Dworniak Daniela, Urbaniak Anna, Terlecka Monika, Paradowski Marek
Zakład Diagnostyki Laboratoryjnej i Biochemii Klinicznej, Katedra Diagnostyki Laboratoryjnej Uniwersytetu Medycznego w Lodź.
Przegl Epidemiol. 2004;58(2):351-9.
The aim of the study was to evaluate dynamics of selected acute phase proteins in serum and cerebrospinal fluid (CSF) in children with viral meningitis and to assess diagnostic power of protein determination for detection and treatment monitoring. 51 children with viral meningitis caused by ECHO 30 virus were included in the study group. Concentration of C-reactive protein (CRP), alpha 1-antitrypsin (AAT), alpha1-acid glycoprotein (AAG), alpha2-haptoglobin (HPT) and C3 complement fragment were determined in serum and CSF at entry and at day 14 after admittance to hospital. Control group for serum determination consisted in 30 healthy children (Group K1) and control group for CSF determination consisted in 19 hospitalized children in whom the diagnosis of meningitis was not confirmed (group K2). The greatest rise of acute phase proteins concentration was observed in children in case of HPT, AAG and C3 complement when determined in serum. Meningitis in children that was caused by ECHO 30 virus produces slight acute phase reaction that is more evident in serum than in CSF. It is confirmed by remarkable increase of AAG, HPT, C3 complement in serum and HPT in CSF either at entry or at the day 14. The determination of AAG, HPT and C3 complement in serum have diagnostic power that is strong enough to meningitis diagnostics and monitoring of treatment.
本研究的目的是评估病毒性脑膜炎患儿血清和脑脊液（CSF）中所选急性期蛋白的动态变化，并评估蛋白测定对检测和治疗监测的诊断价值。51例由ECHO 30病毒引起的病毒性脑膜炎患儿被纳入研究组。在入院时和入院后第14天测定血清和脑脊液中C反应蛋白（CRP）、α1抗胰蛋白酶（AAT）、α1酸性糖蛋白（AAG）、α2-触珠蛋白（HPT）和C3补体片段的浓度。血清测定的对照组由30名健康儿童组成（K1组），脑脊液测定的对照组由19名未确诊为脑膜炎的住院儿童组成（K2组）。在血清中测定时，HPT、AAG和C3补体在患儿中急性期蛋白浓度升高最为明显。由ECHO 30病毒引起的儿童脑膜炎产生轻微的急性期反应，血清中比脑脊液中更明显。入院时或第14天血清中AAG、HPT、C3补体以及脑脊液中HPT的显著增加证实了这一点。血清中AAG、HPT和C3补体的测定具有足够强的诊断能力，可用于脑膜炎的诊断和治疗监测。
