Adly C, Straumanis J, Chesson A
Department of Psychiatry, Louisiana State University School of Medicine, Shreveport.
Headache. 1992 Feb;32(2):101-4. doi: 10.1111/j.1526-4610.1992.hed3202101.x.
Many patients with severe migraine remain refractory to the current treatment regimens or cannot tolerate the side effects. Since current research implicates serotonin dysregulation in migraine pathogenesis, we investigated in a double blind, placebo controlled study the prophylactic effect of the serotonergic drug fluoxetine. Sixteen subjects were randomly assigned to 8 week fluoxetine treatment and 16 to the placebo group; nine subjects in each group completed the study. Migraine headache scores were obtained for two weeks prior to commencement of treatment, and then for each successive two week period. Zung depression scores were obtained before and after completion of the study. Fluoxetine caused significant reduction in headache scores starting with weeks 3-4 of treatment; there was no significant change with placebo. Depression scores did not differ between groups before treatment, and did not significantly change with either treatment. Fluoxetine appears to be a safe and effective drug for migraine prophylaxis, and deserves further therapeutic trials with larger groups for longer periods of time.
许多重度偏头痛患者对当前的治疗方案仍无反应或无法耐受其副作用。由于目前的研究表明血清素失调与偏头痛的发病机制有关，我们在一项双盲、安慰剂对照研究中调查了血清素能药物氟西汀的预防效果。16名受试者被随机分配到接受为期8周的氟西汀治疗组，另外16名被分配到安慰剂组；每组有9名受试者完成了研究。在治疗开始前两周获取偏头痛头痛评分，然后在随后的每两周期间获取评分。在研究完成前后获取zung抑郁评分。从治疗第3 - 4周开始，氟西汀使头痛评分显著降低；安慰剂组无显著变化。治疗前两组的抑郁评分无差异，两种治疗方法也均未使其发生显著变化。氟西汀似乎是一种安全有效的偏头痛预防药物，值得进一步开展更大规模、更长时间的治疗试验。
