Cocca Claudia, Nuñez Mariel, Gutiérrez Alicia, Martín Gabriela, Cricco Graciela, Medina Vanina, Mohamad Nora, Rivera Elena, Bergoc Rosa
Radioisotopes Laboratory, School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina.
Anticancer Res. 2004 Sep-Oct;24(5A):2953-65.
Insulin growth factors (IGFs) are important mediators of growth, development, differentiation and survival of normal and transformed cells. Many complex and diverse types of molecules modulate these actions. In vitro and in vivo experiments have demonstrated that this system (IGF) is strongly related to the establishment of the transformed phenotype. Recent studies confirmed the association between serum levels of IGF-I and diverse malignant diseases while some relationships with other pathologies since Diabetes Mellitus have been described. Currently, IGFs are considered important targets for the study of new therapeutic drugs and strategies for cancer treatment. In this review, we have summarized the latest data specially linking IGF-I and its receptor with breast cancer.
胰岛素生长因子（IGFs）是正常细胞和转化细胞生长、发育、分化及存活的重要调节因子。许多复杂多样的分子调节这些作用。体外和体内实验表明，该系统（IGF）与转化表型的建立密切相关。近期研究证实了血清IGF-I水平与多种恶性疾病之间的关联，同时也描述了其与包括糖尿病在内的其他一些病理状况的关系。目前，IGFs被认为是癌症治疗新治疗药物和策略研究的重要靶点。在本综述中，我们总结了特别将IGF-I及其受体与乳腺癌联系起来的最新数据。
