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[生物学与医学中的新测量技术:原子力显微镜(第三部分)]

[New measurement techniques in biology and medicine: atomic force microscopy (part III)].

作者信息

Miklaszewska Monika, Targosz Marta, Sułowicz Władysław, Pietrzyk Jacek A, Szymoński Marek, Rumian Roman, Krawentek Lidia, Korohoda Przemysław

机构信息

Zaklad i Oddział Dializ Katedry Pediatrii, Polsko-Amerykańskiego Instytutu Pediatrii, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.

出版信息

Przegl Lek. 2004;61(3):192-8.

Abstract

Biological samples can be investigated with atomic force microscopy (AFM) in either of two imaging modes: contact mode or tapping mode. Applications of fluid tapping mode AFM in biology and medical sciences are constantly growing and the data obtained with this technique are improving, especially in terms of resolution. Even dynamic processes can be observed almost as they would occur in vivo. AFM is a proven imaging technique that has recently gained attention in biomaterials due to its ability to analyze surface properties, non-destructively at nanometer-level resolution in ambient air or in fluid environments.

摘要

生物样品可以通过原子力显微镜(AFM)以两种成像模式之一进行研究:接触模式或轻敲模式。流体轻敲模式AFM在生物学和医学科学中的应用不断增加,并且用该技术获得的数据也在不断改善,特别是在分辨率方面。甚至动态过程几乎都可以像在体内发生时那样被观察到。AFM是一种经过验证的成像技术,由于其能够在环境空气或流体环境中以纳米级分辨率进行无损分析表面特性,最近在生物材料领域受到了关注。

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