Sarkar Devanand, Boukerche Habib, Su Zao-Zhong, Fisher Paul B
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, United States.
Pharmacol Ther. 2004 Nov;104(2):101-15. doi: 10.1016/j.pharmthera.2004.08.004.
PDZ (an acronym representing three proteins--postsynaptic density protein PSD95/SAP90, drosophila tumor suppressor DLGA, and tight junction protein ZO-1) domain containing proteins are adapter proteins that play indispensable roles in regulating cell growth, development, and differentiation, predominantly through their capacity to serve as central organizers of protein complexes at the plasma membrane. A recently identified member of this protein family is melanoma differentiation associated gene-9 (mda-9), also known as syntenin, which was first identified as a gene down-regulated during human melanoma differentiation as mda-9 and subsequently recognized as an interacting partner of the cell-surface heparan sulfate syndecans, syntenin. Interest in mda-9/syntenin is intensifying because of its involvement in organization of protein complexes in the plasma membranes, regulation of B cell development, intracellular trafficking and cell surface targeting, cancer metastasis, synaptic transmission, and axonal outgrowth. In this review, we discuss the identification, structure and function of mda-9/syntenin and delineate future studies to address its role in regulating key physiological and pathological processes.
含有PDZ（由三种蛋白质的首字母缩写组成——突触后致密蛋白PSD95/SAP90、果蝇肿瘤抑制因子DLGA和紧密连接蛋白ZO-1）结构域的蛋白质是衔接蛋白，主要通过其作为质膜上蛋白质复合物的核心组织者的能力，在调节细胞生长、发育和分化中发挥不可或缺的作用。该蛋白质家族最近鉴定出的一个成员是黑色素瘤分化相关基因9（mda-9），也称为syntenin，它最初作为在人类黑色素瘤分化过程中下调的基因mda-9被鉴定出来，随后被认为是细胞表面硫酸乙酰肝素多配体蛋白聚糖syntenin的相互作用伴侣。由于mda-9/syntenin参与质膜中蛋白质复合物的组织、B细胞发育的调节、细胞内运输和细胞表面靶向、癌症转移、突触传递和轴突生长，人们对它的兴趣正在增强。在这篇综述中，我们讨论了mda-9/syntenin的鉴定、结构和功能，并描述了未来研究以探讨其在调节关键生理和病理过程中的作用。
