van Veen Vincent, Holroyd Clay B, Cohen Jonathan D, Stenger V Andrew, Carter Cameron S
Department of Psychology, University of Pittsburgh, PA, USA.
Brain Cogn. 2004 Nov;56(2):267-76. doi: 10.1016/j.bandc.2004.06.007.
Recent theories of the neural basis of performance monitoring have emphasized a central role for the anterior cingulate cortex (ACC). Replicating an earlier event-related potential (ERP) study, which showed an error feedback negativity that was modeled as having an ACC generator, we used event-related fMRI to investigate whether the ACC would differentiate between correct and incorrect feedback stimuli in a time estimation task. The design controlled for response conflict and frequency and expectancy effects. Although participants in the current study adjusted their performance following error feedback, we did not observe error feedback-evoked ACC activity. In contrast, we did observe ACC activity while the same subjects performed the Stroop task, in which an area of the ACC activated during both conflict and error trials. These findings are inconsistent with previous dipole models of the error feedback negativity, and suggest the ACC may not be involved in the generation of this ERP component. These results question involvement of the ACC in the detection of errors per se when controlling for conflict.
近期关于绩效监测神经基础的理论强调了前扣带回皮质（ACC）的核心作用。重复一项早期的事件相关电位（ERP）研究，该研究显示了一种被建模为具有ACC发生器的错误反馈负波，我们使用事件相关功能磁共振成像（fMRI）来研究在时间估计任务中ACC是否能区分正确和错误的反馈刺激。该设计控制了反应冲突、频率和预期效应。尽管本研究中的参与者在错误反馈后调整了他们的表现，但我们并未观察到错误反馈诱发的ACC活动。相比之下，当相同的受试者执行Stroop任务时，我们确实观察到了ACC活动，在该任务中，ACC的一个区域在冲突和错误试验期间均被激活。这些发现与先前错误反馈负波的偶极子模型不一致，并表明ACC可能不参与该ERP成分的产生。这些结果质疑了在控制冲突时ACC是否参与错误本身的检测。
