Horwath-Winter Jutta, Vidic Bertram, Schwantzer Gerold, Schmut Otto
Department of Ophthalmology, University of Graz, Graz, Austria.
J Cataract Refract Surg. 2004 Nov;30(11):2316-21. doi: 10.1016/j.jcrs.2004.03.042.
To investigate the changes in corneal sensation, ocular surface integrity, and tear-film function after laser-assisted subepithelial keratectomy (LASEK).
Department of Ophthalmology, University of Graz, Graz, Austria.
Laser-assisted subepithelial keratectomy was performed in 21 consecutive patients (37 myopic eyes). The patients were observed for subjective complaints of dry eye, corneal sensation, tear-film breakup time (BUT), Schirmer test without local anesthesia, and fluorescein and lissamin-green staining preoperatively and 1 week and 1, 3, and 6 months postoperatively.
The subjective score for dry-eye symptoms was not statistically significantly higher after the procedure. Corneal sensation was reduced up to 1 month after LASEK (P<.05). There were obvious decreases in BUT at 1 week and 1 month (P<.01) and no significant changes in Schirmer test results. In fluorescein staining of the cornea, dots were more concentrated at 1 week (P<.05). In lissamin-green staining, no significant changes were found at any follow-up examination.
Laser-assisted subepithelial keratectomy induced a short-term reduction in corneal sensation and affected the ocular surface and tear film slightly. Epithelial flap repositioning in LASEK may have a positive influence on tear-film and ocular-surface factors.
探讨准分子激光上皮下角膜磨镶术（LASEK）后角膜感觉、眼表完整性和泪膜功能的变化。
奥地利格拉茨大学眼科。
对21例连续患者（37只近视眼）实施准分子激光上皮下角膜磨镶术。术前及术后1周、1、3和6个月观察患者干眼主观症状、角膜感觉、泪膜破裂时间（BUT）、无局部麻醉下的Schirmer试验以及荧光素和丽丝胺绿染色情况。
术后干眼症状主观评分无统计学显著升高。LASEK术后1个月内角膜感觉降低（P<0.05）。1周和1个月时BUT明显降低（P<0.01），Schirmer试验结果无显著变化。角膜荧光素染色中，1周时点状染色更集中（P<0.05）。丽丝胺绿染色在任何随访检查中均未发现显著变化。
准分子激光上皮下角膜磨镶术导致角膜感觉短期降低，并轻微影响眼表和泪膜。LASEK中上皮瓣复位可能对泪膜和眼表因素有积极影响。
