钾通道开放剂和钙通道阻滞剂对电驱动大鼠右心室肌条力反应的影响。

Effects of potassium channel openers and calcium channel blockers on the force responses of the electrically driven rat right ventricle strip.

Bishop B E, Doggrell S A

Department of Pharmacology, School of Medicine, University of Auckland, New Zealand.

J Auton Pharmacol. 1992 Feb;12(1):5-14. doi: 10.1111/j.1474-8673.1992.tb00328.x.

Abstract

The effects of potassium channel openers (cromakalim and pinacidil) and of calcium channel blockers (verapamil, diltiazem and flunarizine) on the contractile responses of the rat right ventricle have been determined. 2. On the electrically driven rat right ventricle cromakalim at 3 x 10(-7), 10(-6), 3 x 10(-6) M and 10(-5) M, and pinacidil at 10(-6), 10(-5) and 3 x 10(-5) M had no effect on the force responses to cardiac stimulation or to isoprenaline. 3. Pinacidil at 10(-4) M in a vehicle of 0.7% ethanol reduced the force responses to cardiac stimulation. This inhibitory effect was solely due to the ethanol. Pinacidil in 5 x 10(-4) M HCl (which had no effect alone) potentiated some of the responses to isoprenaline. 4. Verapamil, greater than or equal to 10(-6) M, diltiazem, greater than or equal to 10(-5) M, and flunarizine, greater than or equal to 10(-6) M, reduced the force responses to cardiac stimulation and to isoprenaline. 5. The present study has shown that calcium channel blockers, but not potassium channel openers, have inhibitory effects on the rat right ventricle.

摘要

已测定钾通道开放剂（克罗卡林和匹那地尔）及钙通道阻滞剂（维拉帕米、地尔硫䓬和氟桂利嗪）对大鼠右心室收缩反应的影响。2. 在电驱动的大鼠右心室上，3×10⁻⁷、10⁻⁶、3×10⁻⁶M和10⁻⁵M的克罗卡林以及10⁻⁶、10⁻⁵和3×10⁻⁵M的匹那地尔对心脏刺激或异丙肾上腺素引起的力反应均无影响。3. 在0.7%乙醇载体中10⁻⁴M的匹那地尔降低了对心脏刺激的力反应。这种抑制作用完全归因于乙醇。5×10⁻⁴M盐酸中的匹那地尔（单独无作用）增强了对异丙肾上腺素的一些反应。4. 维拉帕米≥10⁻⁶M、地尔硫䓬≥10⁻⁵M和氟桂利嗪≥10⁻⁶M降低了对心脏刺激和异丙肾上腺素的力反应。5. 本研究表明，钙通道阻滞剂而非钾通道开放剂对大鼠右心室有抑制作用。