Soares D V, Conceição F L, Brasil R R L O, Spina L D C, Lobo P M, Silva E M C, Buescu A, Vaisman M
Service of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Brazil.
Growth Horm IGF Res. 2004 Dec;14(6):436-41. doi: 10.1016/j.ghir.2004.06.004.
To evaluate the variation of serum IGF-1 levels during GH replacement and observe gender differences, 29 adults with GH deficiency (mean age 42.5 +/- 10.1 year), were studied. Serum IGF-1 was assessed every 4 weeks during the titration period and afterwards every 3 months of GH therapy. At baseline 77.7% of women and 45.4% of men had serum baseline IGF-1 levels below the lower limit of normal age-related reference range. The time to reach the maintenance dose was lower in men than women (p < 0.05). There was an increase in IGF-1 levels after one year of GH therapy, significant only in men (p < 0.01). IGF-1 concentrations were higher in men than women (p < 0.05), at the 12th and 18th months of GH therapy. GH dose was reduced by 25% in men (p < 0.01). At the end of the study the mean GH dose was lower in men than in women (p < 0.05). The factor responsible for these findings is not known, however a possible role of androgens has been suggested.
为评估生长激素（GH）替代治疗期间血清胰岛素样生长因子-1（IGF-1）水平的变化并观察性别差异，对29例成人生长激素缺乏症患者（平均年龄42.5±10.1岁）进行了研究。在滴定期每4周评估一次血清IGF-1水平，之后在生长激素治疗的每3个月评估一次。基线时，77.7%的女性和45.4%的男性血清IGF-1水平低于正常年龄相关参考范围的下限。男性达到维持剂量的时间比女性短（p<0.05）。生长激素治疗一年后IGF-1水平升高，仅在男性中显著（p<0.01）。在生长激素治疗的第12个月和第18个月，男性的IGF-1浓度高于女性（p<0.05）。男性的生长激素剂量降低了25%（p<0.01）。研究结束时，男性的平均生长激素剂量低于女性（p<0.05）。造成这些结果的因素尚不清楚，不过有人提出雄激素可能起了作用。
