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乳腺导管原位癌的手术治疗与预后:澳大利亚一项基于人群的研究。

Surgery and outcomes of ductal carcinoma in situ of the breast: a population-based study in Australia.

作者信息

Kricker Anne, Armstrong Bruce

机构信息

School of Public Health, Level 6, Medical Foundation Building K25, University of Sydney, Sydney, NSW 2006, Australia.

出版信息

Eur J Cancer. 2004 Nov;40(16):2396-402. doi: 10.1016/j.ejca.2004.07.008.

Abstract

We examined surgery and outcome in a population-based series of 2109 women newly diagnosed with ductal carcinoma in situ (DCIS) in 1995-2000 in New South Wales (NSW), Australia. The sole data source for the study was pathology records in the NSW Cancer Registry. Most DCIS was treated with breast-conserving surgery (BCS); use of breast conservation increased throughout the 6 years of the study. Women who were younger, had higher grade DCIS or had larger lesions were significantly and independently less likely to have BCS than other women. Eighteen percent of women had lymph nodes removed, most often with mastectomy. The NSW Cancer Registry does not collect information about radiotherapy. Based on cancer registrations alone, 97.7% of women were free of ipsilateral invasive cancer after three years; more women who had mastectomy were cancer-free (100%) than women who had breast-conserving surgery (97.2%; P=0.05).

摘要

我们对1995年至2000年在澳大利亚新南威尔士州(NSW)新诊断为导管原位癌(DCIS)的2109名女性进行了基于人群的系列手术及预后研究。该研究的唯一数据来源是新南威尔士州癌症登记处的病理记录。大多数DCIS采用保乳手术(BCS)治疗;在研究的6年中,保乳手术的使用率不断增加。年龄较小、DCIS分级较高或病灶较大的女性与其他女性相比,接受BCS的可能性显著且独立降低。18%的女性进行了淋巴结切除,大多数是在乳房切除术中进行的。新南威尔士州癌症登记处不收集放疗信息。仅基于癌症登记数据,97.7%的女性在三年后无同侧浸润性癌;接受乳房切除术的女性无癌生存率(100%)高于接受保乳手术的女性(97.2%;P=0.05)。

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