Brenner Hermann, Rachet Bernard
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D-69115 Heidelberg, Germany.
Eur J Cancer. 2004 Nov;40(16):2494-501. doi: 10.1016/j.ejca.2004.07.022.
Up-to-date monitoring of long-term survival is an important task of population-based and clinical cancer registries. A few years ago, a new method of survival analysis, denoted period analysis, was introduced to provide more up-to-date estimates of long-term survival. However, a prototypical period analysis may not be applicable in situations with delayed recording of incident cases. We introduce herein a hybrid type of analysis that combines elements of both traditional and period analyses which may still be feasible in such settings. The performance of the hybrid type of analysis compared with other design options is empirically evaluated and illustrated for children diagnosed with cancer in the United States. The empirical evaluation indicates that hybrid analysis may be useful to derive more up-to-date estimates of long-term survival compared with traditional design options if there is a strong improvement of survival over time, even in situations with a substantial delay in recording of incident cases.
对长期生存情况进行最新监测是基于人群和临床癌症登记处的一项重要任务。几年前，引入了一种新的生存分析方法，即时期分析，以提供更最新的长期生存估计值。然而，典型的时期分析可能不适用于发病病例记录延迟的情况。我们在此介绍一种混合类型的分析方法，它结合了传统分析和时期分析的要素，在这种情况下仍可能可行。通过实证评估并举例说明了美国癌症患儿混合类型分析与其他设计方案相比的性能。实证评估表明，如果随着时间的推移生存率有显著提高，即使在发病病例记录有大幅延迟的情况下，与传统设计方案相比，混合分析可能有助于得出更最新的长期生存估计值。
