极低出生体重早产儿的继发性表面活性物质缺乏症

[Secondary surfactant deficiencies in extremely low birth weight premature infants].

作者信息

Rivera S, Gaugler C, Langlet C, Villega F, Astruc D, Escande B, Kuhn P, Messer J

机构信息

Service de pédiatrie II, médecine néonatale et réanimation pédiatrique, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, avenue Molière, 67098 Strasbourg cedex, France.

出版信息

Arch Pediatr. 2004 Nov;11(11):1346-50. doi: 10.1016/j.arcped.2004.08.004.

DOI:10.1016/j.arcped.2004.08.004

PMID:15519835

Abstract

Primary deficiency of surfactant is responsible for the respiratory distress syndrome and concerns premature neonates born before 33 weeks of gestation. However, newborns may develop respiratory disorders related to a secondary deficiency or dysfunction of surfactant. We report the course of three extremely low birth weight premature infants who experienced clinical respiratory decompensation at two weeks and showed a marked improvement after exogenous natural surfactant administration.

摘要

表面活性物质的原发性缺乏是导致呼吸窘迫综合征的原因，主要涉及妊娠33周前出生的早产儿。然而，新生儿也可能因表面活性物质的继发性缺乏或功能障碍而出现呼吸系统疾病。我们报告了三名极低出生体重早产儿的病程，他们在两周时出现临床呼吸代偿失调，在给予外源性天然表面活性物质后有显著改善。