Wieser Heinz Gregor, Häne Adrian
Department of Epileptology and Electroencephalography, Neurology Clinic, University Hospital Zurich, Zurich, Switzerland.
Seizure. 2004 Dec;13(8):534-6. doi: 10.1016/j.seizure.2003.12.010.
Retrospectively we analysed postoperative AED treatment in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) who were seizure free following selective amygdalohippocampectomy (AHE). In this subgroup, we compared the patients without AEDs with that in the entire series.
During the year prior to surgery, in the MTLE-HS group, a mean of 2.3 +/- 0.8 AEDs were taken. The percentage of seizure-free MTLE-HS patients without AEDs increases to 40% from the postoperative year 5 on. In the ILAE Class 1a (seizure- and aura-free since surgery) at postoperative year 5 more than 60% and from postoperative year 7 on more than 90% have discontinued AED intake.
These figures indicate that reduction and discontinuation of AEDs is the same in the subgroup "seizure-free MTLE-HS patients" compared to the entire series.
我们回顾性分析了内侧颞叶癫痫伴海马硬化（MTLE-HS）患者在选择性杏仁核海马切除术（AHE）后无癫痫发作的情况下的术后抗癫痫药物（AED）治疗情况。在这个亚组中，我们将未使用AED的患者与整个系列中的患者进行了比较。
在手术前一年，MTLE-HS组平均服用2.3±0.8种AED。术后第5年起，未使用AED的无癫痫发作的MTLE-HS患者比例增至40%。在术后第5年，国际抗癫痫联盟（ILAE）1a级（自手术起无癫痫发作和先兆）患者中超过60%，术后第7年起超过90%已停止服用AED。
这些数据表明，与整个系列相比，“无癫痫发作的MTLE-HS患者”亚组中AED的减少和停用情况相同。
