Tóvári József, Bereczky Bíborka, Gilly Réka, Skopál Judit, Vágó Agnes, Tímár József
Országos Onkológiai Intézet, Budapest 1122, Hungary.
Magy Onkol. 2004;48(3):235-41. Epub 2004 Nov 1.
Heparin treatment, at human equivalent doses, modulates coagulation parameters in mice similarly to the human situation. Heparins were tested in various melanoma metastasis models for their antimetastatic activity. Heparins were active against melanoma metastasis without influencing the primary tumor. Tumor cell-induced platelet aggregation was not the primary target of heparins, since melanoma cells were not active in this respect. Our results support the notion that heparins have antimetastatic activity.
以等效于人体的剂量进行肝素治疗时，对小鼠凝血参数的调节与人体情况相似。在各种黑色素瘤转移模型中测试了肝素的抗转移活性。肝素对黑色素瘤转移具有活性，且不影响原发性肿瘤。肿瘤细胞诱导的血小板聚集不是肝素的主要作用靶点，因为黑色素瘤细胞在这方面没有活性。我们的结果支持肝素具有抗转移活性这一观点。
