Thornton M J, Kennedy M L, Lubowski D Z, King D W
Department of Colorectal Surgery, St George Hospital, Sydney Colorectal Associates, University of New South Wales, Sydney.
Colorectal Dis. 2004 Nov;6(6):470-6. doi: 10.1111/j.1463-1318.2004.00714.x.
This paper presents the long-term morbidity, function and quality of life data for patients who have undergone dynamic graciloplasty (DGP) for faecal incontinence.
All patients (n = 38) who had undergone DGP at one institution between 1993 and 2003 are presented. Thirty-three were available for long-term follow-up (median 60 months) and completed a telephone questionnaire assessing quality of life (QOL), bowel and sexual function and patient satisfaction. All patients had interval anorectal physiology studies.
At a median follow-up of 5 years, 72% had pain, swelling or paraesthesia in the donor leg and 27% had sexual dysfunction. Sixteen percent of patients had been converted to an end-colostomy for persisting incontinence and 11% for obstructed defaecation. All other patients have a normally functioning graciloplasty. Sixteen percent of patients reported a faecal continence score < 12. Of those patients with a functioning graciloplasty, 50% had obstructed defaecation and 64% reported that their bowel dysfunction had a negative impacted on their QOL. Age, medical comorbidity and anal manometry did not correlate with functional outcome. Quality of life scores and patient satisfaction scores correlated significantly with continence scores. There was a trend toward higher QOL and satisfaction scores with conversion to colostomy compared with a continence score > 12. Sixty percent of patients rated their satisfaction with DGP as 50% or better on a visual analogue scale, and this correlated strongly with the continence score at the time of the assessment (P < 0.001).
Dynamic graciloplasty significantly improves patient quality of life and anal continence for some patients. Despite increased experience, morbidity remains high and long-term continence scores are poor in a majority of cases. Obstructed defaecation is a significant problem after graciloplasty and antegrade colonic enemas may be needed. Significant prognostic factors for obstructed defaecation remain to be identified. The mechanism of both continence failure and surgical morbidity remains poorly defined in many patients and requires further investigation. The individual patient can expect a 16% chance of normal faecal continence at 5 years, with at least one surgical morbidity as a result of the procedure.
本文介绍了接受动态股薄肌成形术(DGP)治疗大便失禁患者的长期发病率、功能及生活质量数据。
纳入1993年至2003年间在同一机构接受DGP治疗的所有患者(n = 38)。33例患者接受了长期随访(中位时间60个月),并完成了一份电话调查问卷,评估生活质量(QOL)、肠道及性功能以及患者满意度。所有患者均进行了间隔性的肛肠生理研究。
中位随访5年时,72%的患者供体腿出现疼痛、肿胀或感觉异常,27%的患者出现性功能障碍。16%的患者因持续性失禁改行末端结肠造口术,11%的患者因排便梗阻改行该术式。所有其他患者的股薄肌成形术功能正常。16%的患者报告大便失禁评分<12。在股薄肌成形术功能正常的患者中,50%存在排便梗阻,64%的患者报告其肠道功能障碍对生活质量有负面影响。年龄、合并症及肛门测压与功能结局无关。生活质量评分和患者满意度评分与失禁评分显著相关。与失禁评分>12相比,改行结肠造口术的患者生活质量和满意度评分有升高趋势。60%的患者在视觉模拟量表上对DGP的满意度评分为50%或更高,这与评估时的失禁评分密切相关(P < 0.001)。
动态股薄肌成形术可显著改善部分患者的生活质量和肛门节制功能。尽管经验增多,但发病率仍然较高,大多数病例的长期失禁评分较差。排便梗阻是股薄肌成形术后的一个重要问题,可能需要进行顺行结肠灌肠。排便梗阻的重要预后因素仍有待确定。许多患者大便失禁失败和手术发病率的机制仍不清楚,需要进一步研究。个体患者在5年后大便正常节制的几率为16%,且该手术至少会导致一种手术相关并发症。