Christidou A, Gikas A, Scoulica E, Pediaditis J, Roumbelaki M, Georgiladakis A, Tselentis Y
Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Crete, Greece.
Clin Microbiol Infect. 2004 Nov;10(11):999-1005. doi: 10.1111/j.1469-0691.2004.00992.x.
The aim of this study was to investigate the clinical and epidemiological characteristics of five consecutive cases of infection with vancomycin-resistant enterococci (VRE) and the prevalence of faecal carriage of VRE among patients admitted to a 700-bed university hospital where no VRE had been isolated previously. In a 2-month period, five consecutive patients infected with VRE were detected. Three VanB+ Enterococcus faecium isolates were obtained from three patients, while two VanA+ E. faecium isolates, one VanA+ Enterococcus faecalis isolate and one VanC1+ Enterococcus gallinarum isolate were obtained from the other two patients. Of 218 faecal specimens from all hospital wards, 41 (18.8%) were found to contain VRE. Forty-two isolates of VRE were obtained, comprising one (2%) E. faecalis, 11 (27%) E. faecium, 24 (57%) E. gallinarum and six (14%) Enterococcus casseliflavus/flavescens. Four isolates carried the vanA gene, eight carried vanB, 24 carried vanC1, and six carried vanC2/C3. Use of glycopeptides, the presence of central venous catheters and renal dialysis all correlated with VRE colonisation. The prevalence rates were among the highest reported in the literature.
本研究旨在调查5例耐万古霉素肠球菌（VRE）感染的连续病例的临床和流行病学特征，以及在一家此前未分离出VRE的拥有700张床位的大学医院住院患者中VRE粪便携带率。在2个月的时间里，检测到5例连续的VRE感染患者。从3例患者中获得了3株VanB+屎肠球菌分离株，而从另外2例患者中获得了2株VanA+屎肠球菌分离株、1株VanA+粪肠球菌分离株和1株VanC1+鹑鸡肠球菌分离株。在来自医院所有病房的218份粪便标本中，41份（18.8%）被发现含有VRE。获得了42株VRE分离株，包括1株（2%）粪肠球菌、11株（27%）屎肠球菌、24株（57%）鹑鸡肠球菌和6株（14%）格氏肠球菌/微黄肠球菌。4株分离株携带vanA基因，8株携带vanB，24株携带vanC1，6株携带vanC2/C3。糖肽类药物的使用、中心静脉导管的存在和肾透析均与VRE定植相关。该携带率是文献报道中最高的之一。
