Vogel Ida, Petersen Astrid, Petersen Lone Kjeld, Helmig Rikke Bek, Oxlund Hans, Uldbjerg Niels
Department of Obstetrics and Gynecology, University Hospital of Aarhus, Skejby, DK-8200 Aarhus N, Denmark.
In Vivo. 2004 Sep-Oct;18(5):581-4.
Relaxin has been proposed as a hormone involved in the collagen remodeling of the utero-placental unit.
Human fetal membrane explants were incubated with H1 or H2 relaxin for 48 hours and stretched until rupture in a materials testing machine. Co-incubation with a synthetic collagenase inhibitor was performed in order to examine whether the effects of relaxin could be inhibited. The effects on hydroxyproline and histology were evaluated.
Biomechanical testing showed that H2 relaxin induced a biphasic weakening of human fetal membranes, an effect that was abolished after co-incubation with a collagenase inhibitor. H1 relaxin produced no significant effects on the biomechanical properties. The effects of H2 relaxin on the biomechanical properties were, however, not followed by changes in the hydroxyproline concentration or the histology.
H2 relaxin had an effect on human fetal membranes and this effect may be mediated through collagenases.
松弛素被认为是一种参与子宫 - 胎盘单位胶原重塑的激素。
将人胎膜外植体与H1或H2松弛素孵育48小时，然后在材料试验机中拉伸直至破裂。为了研究松弛素的作用是否能被抑制，进行了与合成胶原酶抑制剂的共同孵育。评估了对羟脯氨酸和组织学的影响。
生物力学测试表明，H2松弛素诱导人胎膜出现双相减弱，与胶原酶抑制剂共同孵育后该效应消失。H1松弛素对生物力学性能无显著影响。然而，H2松弛素对生物力学性能的影响并未伴随羟脯氨酸浓度或组织学的变化。
H2松弛素对人胎膜有影响，且这种影响可能是通过胶原酶介导的。
