Keserü György Miklós
CADD&HTS, Richter Gedeon Rt., 1103 Budapest, Gyömroiút 19-21.
Acta Pharm Hung. 2004;74(1):5-10.
High throughput screening (HTS) became an integral part of the early phase drug discovery process. Although the methodology itself is widely accepted as a powerful tool of lead discovery there are a number of positive and also negative opinions associated to its application. This paper gives a short introduction to HTS technology, summarizes primary experiences and points out latest changes in screening strategy and technology. Development and application of the new screening facility of Gedeon Richter is also reported.
高通量筛选（HTS）已成为早期药物发现过程中不可或缺的一部分。尽管该方法本身作为一种强大的先导化合物发现工具已被广泛接受，但对于其应用仍存在一些积极和消极的看法。本文简要介绍了高通量筛选技术，总结了主要经验，并指出了筛选策略和技术的最新变化。同时还报道了吉瑞大药厂新筛选设施的开发与应用情况。
