Sainz-Trapága M, Masoller C, Braun H A, Huber M T
Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Sep;70(3 Pt 1):031904. doi: 10.1103/PhysRevE.70.031904. Epub 2004 Sep 15.
We explore the dynamics of a Hodgkin-Huxley-type model for thermally sensitive neurons that exhibit intrinsic oscillatory activity. The model is modified to include a feedback loop that is represented by two parameters: the synaptic strength and the transmission delay time. We analyze the dynamics of the neuron depending on the temperature, the synaptic strength, and the delay time. We find parameter regions where the effect of the recurrent connexion is excitatory, inducing spikes or trains of spikes, and regions where it is inhibitory, reducing or eliminating completely the spiking behavior. We characterize the complex interplay of the intrinsic dynamics of the neuron with the recurrent feedback input and a noisy input.
我们研究了用于表现出内在振荡活动的热敏神经元的霍奇金 - 赫胥黎型模型的动力学。该模型经过修改，纳入了一个由两个参数表示的反馈回路：突触强度和传输延迟时间。我们根据温度、突触强度和延迟时间来分析神经元的动力学。我们发现了循环连接效应具有兴奋性（诱导产生尖峰或尖峰序列）的参数区域，以及其具有抑制性（减少或完全消除尖峰行为）的区域。我们刻画了神经元内在动力学与循环反馈输入以及噪声输入之间的复杂相互作用。
