Dimri Goberdhan P
Division of Cancer Biology, Department of Medicine, Evanston, Northwestern Healthcare Research Institute, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60201, USA.
Sci Aging Knowledge Environ. 2004 Nov 3;2004(44):pe40. doi: 10.1126/sageke.2004.44.pe40.
Although several biomarkers of aging have been described in the literature, it is only recently that gerontologists have started to search for molecular biomarkers of aging. A gene or a set of genes that are expressed in a wide range of tissues and exhibit an age-dependent, easily quantifiable increase in their expression represent a possible molecular biomarker of aging. Because the physiology of an organism is profoundly affected by the pattern of gene expression, it is hoped that molecular biomarkers of aging will more accurately predict the physiological age of an organism than the chronological age. A recent report from Sharpless's laboratory examines the possibility that the tumor suppressors p16 and ARF (encoded by the INK4a/ARF locus) represent molecular biomarkers of aging in rodent models.
尽管文献中已经描述了几种衰老生物标志物，但直到最近老年医学专家才开始寻找衰老的分子生物标志物。在广泛的组织中表达且其表达呈现年龄依赖性、易于定量增加的一个基因或一组基因代表了一种可能的衰老分子生物标志物。由于生物体的生理学受到基因表达模式的深刻影响，人们希望衰老的分子生物标志物比实际年龄更准确地预测生物体的生理年龄。夏普利斯实验室最近的一份报告探讨了肿瘤抑制因子p16和ARF（由INK4a/ARF基因座编码）在啮齿动物模型中代表衰老分子生物标志物的可能性。
