Phornchirasilp S, Lockwood R
Arch Int Pharmacodyn Ther. 1977 Jan;225(1):98-103.
Cyclic AMP levels were measured in cardiac and vascular tissues removed from pentobarbitone-anesthetized rats pretreated with theophylline 45 mg/kg i.p. Noradrenaline, 20 microng/kg i.v., increased cardiac but not vascular cyclic AMP levels; this selective effect of noradrenaline was not altered by pretreatment with phenoxybenzamine, 1 mg/kg i.v. Tazolol, 120 microng/kg i.v., selectively increased cardiac cyclic AMP levels whereas fenoterol, 15 microng/kg i.v., selectively increased vascular cyclic AMP levels. The results suggest that adenylate cyclase activation in cardiac and vascular tissued in vivo is mediated by beta adrenoceptors which consist of different subtypes.
用45mg/kg腹腔注射茶碱预处理戊巴比妥麻醉的大鼠，然后取出心脏和血管组织，测定其中环磷酸腺苷（cAMP）的水平。静脉注射20μg/kg去甲肾上腺素可提高心脏而非血管组织中cAMP的水平；苯氧苄胺1mg/kg静脉注射预处理并未改变去甲肾上腺素的这种选择性作用。静脉注射120μg/kg替唑洛尔可选择性提高心脏cAMP水平，而静脉注射15μg/kg非诺特罗则可选择性提高血管cAMP水平。结果表明，体内心脏和血管组织中腺苷酸环化酶的激活是由不同亚型的β肾上腺素受体介导的。
