Görg C, Wollenberg B, Beyer J, Stolte M S, Neubauer A
Department of Hematology and Oncology, Philipps-University Marburg, Marburg, Germany.
Ann Hematol. 2005 Jan;84(1):33-9. doi: 10.1007/s00277-004-0893-4. Epub 2004 Sep 1.
Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wall layers throughout the small and large bowel. We report the sonographic findings of seven consecutive patients with histologically confirmed GVHD grade II-IV of the gastrointestinal tract. The patients were examined sonographically within the 1st week after onset of clinical symptoms. Dilatation of the colon and striking bowel wall thickening were early and common features in these patients. Sonography may become a useful tool for diagnosis of patients with gastrointestinal GVHD. Its role for preclinical diagnosis, grading of severity of disease, and guiding therapy of patients with gastrointestinal GVHD warrants evaluation in prospective studies.
胃肠道移植物抗宿主病（GVHD）是异基因造血干细胞移植后与治疗相关死亡的主要原因之一。早期诊断和及时治疗可能对改善临床结局至关重要。高分辨率超声检查可对整个小肠和大肠的肠壁各层进行评估。我们报告了连续7例经组织学证实为胃肠道GVHD II-IV级患者的超声检查结果。这些患者在临床症状出现后的第1周内接受了超声检查。结肠扩张和明显的肠壁增厚是这些患者早期和常见的特征。超声检查可能成为诊断胃肠道GVHD患者的有用工具。其在胃肠道GVHD患者的临床前诊断、疾病严重程度分级及指导治疗方面的作用值得在前瞻性研究中进行评估。
